Reticulocyte transfer RNA and hemoglobin synthesis
نویسندگان
چکیده
منابع مشابه
Reticulocyte hemoglobin equivalent to detect thalassemia and thalassemic hemoglobin variants
INTRODUCTION Thalassemia and iron deficiency may both result in hypochromic microcytic anemia. Hematological algorithms that differentiate the two are mainly established in adult selected diagnostic groups. We aimed at creating an algorithm applicable in the presence of children, hemoglobin variants, and iron deficiency. METHODS Our study material constituted blood samples referred during 1 y...
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As has been well established, reticulocytes (RC) synthesize the species specific protein, globin, actively for about 24 hours or more till the time of their complete maturation1,2,3. This will be possible only in the presence of messenger RNA (m-RNA)4,5. Since the splendid hypothesis of m-RNA proposed by JACOB and MONOD6 for explaining the mechanism of the transfer of genetic information from n...
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This paper presents evidence suggesting that methionyltRNAp is the initiator tRNA for hemoglobin biosynthesis. Our experimental approach was as follows. If the mechanism of mammalian protein synthesis is similar to the mechanism in bacteria, then a tRNA species should be present in the cytoplasm of reticulocytes which has the unique property of being recognized only by its own "initiation" fact...
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The ribosome and initiation factor requirements for translation of rabbit-reticulocyte hemoglobin mRNA on rabbit reticulocyte ribosomes, reticulocyte ribosomal subunits, and liver ribosomes have been studied. Excellent synthesis of globin chains from exogenous mRNA in the fractionated cell-free system has been achieved. There is a near absolute requirement for each of the initiation factors, M(...
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To the Editor: We read with interest the article by Fernandez et al. Reticulocyte hemoglobin content (CHr) is a promising marker of iron metabolism, particularly in the intensive care unit setting where usual markers are often disrupted by inflammation. In a small cohort of critically ill patients with no evidence of real iron deficiency, we observed a correlation between C-reactive protein and...
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ژورنال
عنوان ژورنال: Science
سال: 1976
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.935880